Preview

Topical biotechnology

Advanced search

СРАВНИТЕЛЬНЫЙ МУЛЬТИОМНЫЙ АНАЛИЗ ВЫЯВИЛ КЛЮЧЕВЫЕ ИЗМЕНЕНИЯ, ПРОИЗОШЕДШИЕ В ПРОГРАММЕ КЛАССИЧЕСКОГО УЛУЧШЕНИЯ ШТАММА ACREMONIUM CHRYSOGENUM RNCM F-408D ДЛЯ ПРОДУКЦИИ АНТИБИОТИКА ЦЕФАЛОСПОРИНА С

https://doi.org/10.20914/2304-4691-2025-3-7-8

About the Authors

А. Жгун
ФИЦ Биотехнологии РАН
Russian Federation


М. Думина
ФИЦ Биотехнологии РАН
Russian Federation


А. Белецкий
ФИЦ Биотехнологии РАН
Russian Federation


А. Копылов
Институт биомедицинской химии РАМН
Russian Federation


В. Згода
Институт биомедицинской химии РАМН
Russian Federation


References

1. Aminov R.I. A brief history of the antibiotic era: lessons learned and challenges for the future // Frontiers in Microbiology. 2010. Vol. 1. 134.

2. Aly A.H., Debbab A., Proksch P. Fifty years of drug discovery from fungi // Fungal Diversity. 2011. Vol. 50. P. 3-19.

3. Fouillaud M., Dufossé L. Microbial secondary metabolism and biotechnology // Microorganisms. 2022. Vol. 10. № 1. 123.

4. Keller N.P. Fungal secondary metabolism: regulation, function and drug discovery // Nature Reviews Microbiology. 2019. Vol. 17. P. 167-180.

5. Zhgun A.A. Fungal BGCs for production of secondary metabolites: main types, central roles in strain improvement, and regulation according to the piano principle // International Journal of Molecular Sciences. 2023. Vol. 24. № 13. 11184.

6. Liu L., Chen Z., Liu W. et al. Cephalosporin C biosynthesis and fermentation in Acremonium chrysogenum // Applied Microbiology and Biotechnology. 2022. Vol. 106. № 19. P. 6413-6426.

7. Duan S., Yuan G., Zhao Y. et al. Simulation of computational fluid dynamics and comparison of cephalosporin C fermentation performance with different impeller combinations // Korean Journal of Chemical Engineering. 2013. Vol. 30. № 6. P. 1097-1104.

8. Zhgun A.A. Industrial production of antibiotics in fungi: current state, deciphering the molecular basis of clas sical strain improvement and increasing the production of high-yielding strains by the addition of low-molecular weight inducers // Fermentation. 2023. Vol. 9. № 12. 1027.

9. Newton G.G.F., Abraham E.P. Isolation of cephalosporin C, a penicillin-like antibiotic containing D-alpha aminoadipic acid // Biochemical Journal. 1956. Vol. 62. № 4. P. 651–658.

10. Dumina M.V., Zhgun A.A., Novak M.I. et al. Comparative gene expression profiling reveals key changes in expression levels of cephalosporin C biosynthesis and transport genes between low and high-producing strains of Acremonium chrysogenum // World Journal of Microbiology and Biotechnology. 2014. Vol. 30. № 11. P. 2933–2941.

11. Hyvönen M.T., Keinänen T.A., Nuraeva G.K. et al. Hydroxylamine analogue of agmatine: Magic bullet for arginine decarboxylase // Biomolecules. 2020. Vol. 10. № 3. 406.


Review

For citations:


 ,  ,  ,  ,   . Topical biotechnology. 2025;(3):7-8. (In Russ.) https://doi.org/10.20914/2304-4691-2025-3-7-8

Views: 43

JATS XML


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2304-4691 (Print)