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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actbiotech</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальная биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Topical biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-4691</issn><publisher><publisher-name>ВГУИТ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20914/2304-4691-2025-3-7-8</article-id><article-id custom-type="elpub" pub-id-type="custom">actbiotech-5502</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>СРАВНИТЕЛЬНЫЙ МУЛЬТИОМНЫЙ АНАЛИЗ ВЫЯВИЛ КЛЮЧЕВЫЕ ИЗМЕНЕНИЯ, ПРОИЗОШЕДШИЕ В ПРОГРАММЕ КЛАССИЧЕСКОГО УЛУЧШЕНИЯ ШТАММА ACREMONIUM CHRYSOGENUM RNCM F-408D ДЛЯ ПРОДУКЦИИ АНТИБИОТИКА ЦЕФАЛОСПОРИНА С</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жгун</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Думина</surname><given-names>М. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белецкий</surname><given-names>А. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Копылов</surname><given-names>А. Т.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Згода</surname><given-names>В. Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФИЦ Биотехнологии РАН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биомедицинской химии РАМН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>7</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жгун А.А., Думина М.В., Белецкий А.В., Копылов А.Т., Згода В.Г., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Жгун А.А., Думина М.В., Белецкий А.В., Копылов А.Т., Згода В.Г.</copyright-holder><copyright-holder xml:lang="en">Жгун А.А., Думина М.В., Белецкий А.В., Копылов А.Т., Згода В.Г.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actbio-vsuet.ru/jour/article/view/5502">https://www.actbio-vsuet.ru/jour/article/view/5502</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Aminov R.I. 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