actbiotechАктуальная биотехнологияTopical biotechnology2304-4691ВГУИТ10.20914/2304-4691-2025-2-40-41actbiotech-5498Research ArticleСтатьиФИБРИНОЛИТИЧЕСКАЯ ПРОТЕАЗА ASPERGILLUS OCHRACEUS: РЕКОМБИНАНТНЫЙ СИНТЕЗ И ПОТЕНЦИАЛ ПРИМЕНЕНИЯМирошниковК. А.noemail@neicon.ruКомаревцевС. К.noemail@neicon.ruСтепаненкоВ. Н.noemail@neicon.ruОсмоловскийА. А.noemail@neicon.ruЛоктюшовЕ. В.noemail@neicon.ruИнститут биоорганической химии им. М.М. Шемякина и Ю.А. ОвчинниковаRussian FederationФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова»Russian FederationФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»Russian FederationФГБУН ФИЦ «Пущинский научный центр биологических исследований» РАНRussian Federation202530062025024041Copyright © Мирошников К.А., Комаревцев С.К., Степаненко В.Н., Осмоловский А.А., Локтюшов Е.В., 20252025Мирошников К.А., Комаревцев С.К., Степаненко В.Н., Осмоловский А.А., Локтюшов Е.В.Мирошников К.А., Комаревцев С.К., Степаненко В.Н., Осмоловский А.А., Локтюшов Е.В.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actbio-vsuet.ru/jour/article/view/5498ReferencesOsmolovskiy A.A., Kreyer V.G., Kurakov A.V. et al. Proteolytic activity of soil micromycetes // Applied Biochemistry and Microbiology. 2012. Vol. 48. № 5. P. 488-492. doi: 10.1134/S0003683812050109Osmolovskiy A.A., Kreyer V.G., Kurakov A.V. et al. Proteolytic activity of soil micromycetes // Applied Biochemistry and Microbiology. 2012. Vol. 48. № 5. P. 488-492. doi: 10.1134/S0003683812050109Mohammed S., Favaloro E.J. Laboratory tests for von Willebrand factor // Methods in Molecular Biology. 2017. Vol. 1646. P. 137-143. doi: 10.1007/978-1-4939-7196-1_10Mohammed S., Favaloro E.J. Laboratory tests for von Willebrand factor // Methods in Molecular Biology. 2017. Vol. 1646. P. 137-143. doi: 10.1007/978-1-4939-7196-1_10Nasr A.R., Komarevtsev S.K., Baidamshina D.R. et al. Antifungal activity of Bacillus subtilis strains and their potential for biocontrol of phytopathogens // Biochimie. 2025. Vol.Nasr A.R., Komarevtsev S.K., Baidamshina D.R. et al. Antifungal activity of Bacillus subtilis strains and their potential for biocontrol of phytopathogens // Biochimie. 2025. Vol.P. 33-42. doi: 10.1016/j.biochi.2024.11.002P. 33-42. doi: 10.1016/j.biochi.2024.11.002Osmolovskiy A.A., Orekhova A.V., Kreyer V.G. et al. Antimicrobial potential of fungal proteases against drug-resistant bacteria // Life. 2021. Vol. 11. № 8. 782. doi: 10.3390/life11080782Osmolovskiy A.A., Orekhova A.V., Kreyer V.G. et al. Antimicrobial potential of fungal proteases against drug-resistant bacteria // Life. 2021. Vol. 11. № 8. 782. doi: 10.3390/life11080782Komarevtsev S.K., Evseev P.V., Shneider M.M. et al. Genomic analysis of Bacillus subtilis strains with antifungal activity // Microorganisms. 2021. Vol. 9. № 9. 1936. P. 1-13. doi: 10.3390/microorganisms9091936Komarevtsev S.K., Evseev P.V., Shneider M.M. et al. Genomic analysis of Bacillus subtilis strains with antifungal activity // Microorganisms. 2021. Vol. 9. № 9. 1936. P. 1-13. doi: 10.3390/microorganisms9091936Komarevtsev S.K., Popova E.A., Kreyer V.G. et al. Protease complex from Bacillus subtilis: isolation and properties // Applied Biochemistry and Microbiology. 2020. Vol. 56. № 1. P. 32-36. doi: 10.1134/S0003683820010093Komarevtsev S.K., Popova E.A., Kreyer V.G. et al. Protease complex from Bacillus subtilis: isolation and properties // Applied Biochemistry and Microbiology. 2020. Vol. 56. № 1. P. 32-36. doi: 10.1134/S0003683820010093Pan Y., Yang J., Wu J. et al. Recent advances in microbial proteases for industrial applications // Frontiers in Microbiology. 2022. Vol. 13. 1059777. doi: 10.3389/fmicb.2022.1059777Pan Y., Yang J., Wu J. et al. Recent advances in microbial proteases for industrial applications // Frontiers in Microbiology. 2022. Vol. 13. 1059777. doi: 10.3389/fmicb.2022.1059777Osmolovskiy A.A., Kreyer V.G., Baranova N.A. et al. Fungal proteases as promising biocatalysts for various industries // Applied Biochemistry and Microbiology. 2013. Vol. 49. № 6. P. 581-586. doi: 10.1134/S0003683813060148Osmolovskiy A.A., Kreyer V.G., Baranova N.A. et al. Fungal proteases as promising biocatalysts for various industries // Applied Biochemistry and Microbiology. 2013. Vol. 49. № 6. P. 581-586. doi: 10.1134/S0003683813060148Osmolovskiy A.A., Orekhova A.V., Kreyer V.G. et al. Proteolytic enzymes of microscopic fungi as potential agents for antimicrobial therapy // Biomeditsinskaya Khimiya. 2018. Vol. 64. № 1. P. 115-118.Osmolovskiy A.A., Orekhova A.V., Kreyer V.G. et al. Proteolytic enzymes of microscopic fungi as potential agents for antimicrobial therapy // Biomeditsinskaya Khimiya. 2018. Vol. 64. № 1. P. 115-118.

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