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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actbiotech</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальная биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Topical biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-4691</issn><publisher><publisher-name>ВГУИТ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20914/2304-4691-2024-2-37-41</article-id><article-id custom-type="elpub" pub-id-type="custom">actbiotech-5281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>МЕДЬСОДЕРЖАЩИЕ ОКСИДАЗЫ БАКТЕРИЙ И АРХЕЙ: БИОИНЖЕНЕРИЯ И НАПРАВЛЕННЫЙ ДИЗАЙН</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Понаморева</surname><given-names>О. Н.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубицина</surname><given-names>Л. И.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллатыпов</surname><given-names>А. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трубицин</surname><given-names>И. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егоров</surname><given-names>К. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алферов</surname><given-names>С. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьевский</surname><given-names>А. А.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Тульский государственный университет</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биохимии и физиологии микроорганизмов РАН -обособленное структурное подразделение ФИЦ ПНЦБИ РАН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Институт биохимии и физиологии микроорганизмов РАН - обособленное структурное подразделение ФИЦ ПНЦБИ РАН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>08</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>2</issue><fpage>37</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Понаморева О.Н., Трубицина Л.И., Моисеева А.А., Абдуллатыпов А.В., Трубицин И.В., Егоров К.А., Алферов С.В., Леонтьевский А.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Понаморева О.Н., Трубицина Л.И., Моисеева А.А., Абдуллатыпов А.В., Трубицин И.В., Егоров К.А., Алферов С.В., Леонтьевский А.А.</copyright-holder><copyright-holder xml:lang="en">Понаморева О.Н., Трубицина Л.И., Моисеева А.А., Абдуллатыпов А.В., Трубицин И.В., Егоров К.А., Алферов С.В., Леонтьевский А.А.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actbio-vsuet.ru/jour/article/view/5281">https://www.actbio-vsuet.ru/jour/article/view/5281</self-uri><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке гранта Российского научного фонда № 24-14-20013, https://rscf.ru/project/24-14-20013 и правительства Тульской области.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Orsi, E., et al., Automated in vivo enzyme engineering accelerates biocatalyst optimization. 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