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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actbiotech</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальная биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Topical biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-4691</issn><publisher><publisher-name>ВГУИТ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20914/2304-4691-2020-3-363-364</article-id><article-id custom-type="elpub" pub-id-type="custom">actbiotech-4899</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>ДИНИТРОЗИЛЬНЫЕ КОМПЛЕКСЫ ЖЕЛЕЗА С КАРНОЗИНОМ: СИНТЕЗ, СВОЙСТВА, ОБЛАСТЬ ПРИМЕНЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Космачевская</surname><given-names>О. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шумаев</surname><given-names>К. Б.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Топунов</surname><given-names>А. Ф.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт биохимии им. А.Н. Баха</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>09</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>363</fpage><lpage>364</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Космачевская О.В., Шумаев К.Б., Топунов А.Ф., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Космачевская О.В., Шумаев К.Б., Топунов А.Ф.</copyright-holder><copyright-holder xml:lang="en">Космачевская О.В., Шумаев К.Б., Топунов А.Ф.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actbio-vsuet.ru/jour/article/view/4899">https://www.actbio-vsuet.ru/jour/article/view/4899</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vanin A.F. Dinitrosyl iron complexes with thiol-containing ligands as a «working form» of endogenous nitric oxide. // Nitric Oxide. 2016. 54. 15-29.</mixed-citation><mixed-citation xml:lang="en">Vanin A.F. Dinitrosyl iron complexes with thiol-containing ligands as a «working form» of endogenous nitric oxide. // Nitric Oxide. 2016. 54. 15-29.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Boese M., Mordvintcev P.I., Vanin A.F., Busse R., Mьlsch A.J. S-nitrosation of serum albumin by dinitrosyl-ironc omplex. // J. Biol. Chem. 1995. 270. 29244-29249.</mixed-citation><mixed-citation xml:lang="en">Boese M., Mordvintcev P.I., Vanin A.F., Busse R., Mьlsch A.J. S-nitrosation of serum albumin by dinitrosyl-ironc omplex. // J. Biol. Chem. 1995. 270. 29244-29249.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X., Sunderberg E.B., Li L., Kantardjieff K.A., Herron S.R., Lim M., Ford P.C. A cyclic tetra-nucleardinitrosyl iron complex [Fe(NO)2(imidazolate)]4: synthesis, structure and stability. // Chem. Commun. 2005. 4. 477-479.</mixed-citation><mixed-citation xml:lang="en">Wang X., Sunderberg E.B., Li L., Kantardjieff K.A., Herron S.R., Lim M., Ford P.C. A cyclic tetra-nucleardinitrosyl iron complex [Fe(NO)2(imidazolate)]4: synthesis, structure and stability. // Chem. Commun. 2005. 4. 477-479.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tsai M.C., Tsai F.T., Lu T.T., Tsai M.L., Wei Y.C., Hsu I.J., Lee J.F., Liaw W.F. Relative binding affinity of thiolate, imidazolate, phenoxide, and nitrite toward the {Fe(NO)2} motif of dinitrosyl iron complexes (DNICs): The characteristic pre- edgeenergy of {Fe(NO)2}9DNICs. // Inorg. Chem. 2009. 48. 9579-9591.</mixed-citation><mixed-citation xml:lang="en">Tsai M.C., Tsai F.T., Lu T.T., Tsai M.L., Wei Y.C., Hsu I.J., Lee J.F., Liaw W.F. Relative binding affinity of thiolate, imidazolate, phenoxide, and nitrite toward the {Fe(NO)2} motif of dinitrosyl iron complexes (DNICs): The characteristic pre- edgeenergy of {Fe(NO)2}9DNICs. // Inorg. Chem. 2009. 48. 9579-9591.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy V.P., Garrett M.R., Perry G., Smith M.A. Carnosine: A versatile antioxidant and antiglycating agent. // Sci. Aging Knowl. Environ. 2005. 2005(18). 12.</mixed-citation><mixed-citation xml:lang="en">Reddy V.P., Garrett M.R., Perry G., Smith M.A. Carnosine: A versatile antioxidant and antiglycating agent. // Sci. Aging Knowl. Environ. 2005. 2005(18). 12.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hipkiss A.R., Brownson C. Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageingpeptide? // Biogerontology. 2000. 1. 217-223.</mixed-citation><mixed-citation xml:lang="en">Hipkiss A.R., Brownson C. Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageingpeptide? // Biogerontology. 2000. 1. 217-223.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Decker E.A., Livisay S.A., Zhou S.A. Re-evaluation of the antioxidant activity of purified carnosine. // Biochemistry (Moscow). 2000. 65. 766-770.</mixed-citation><mixed-citation xml:lang="en">Decker E.A., Livisay S.A., Zhou S.A. Re-evaluation of the antioxidant activity of purified carnosine. // Biochemistry (Moscow). 2000. 65. 766-770.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Boldyrev A., Bulygina E., Leinsoo T., Petrushanko I., Tsubone S., Abe H. Protection of neuronal cells against reactive oxygen species by carnosine and related compounds. // Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 2004. 137. 81-88.</mixed-citation><mixed-citation xml:lang="en">Boldyrev A., Bulygina E., Leinsoo T., Petrushanko I., Tsubone S., Abe H. Protection of neuronal cells against reactive oxygen species by carnosine and related compounds. // Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 2004. 137. 81-88.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vanin A.F. Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology. // Nitric Oxide. 2009. 21. 1-13.</mixed-citation><mixed-citation xml:lang="en">Vanin A.F. Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology. // Nitric Oxide. 2009. 21. 1-13.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Decker E.A., Crum A.D., Calvert J.T. Differences in the antioxidant mechanism of carnosine in the presence of copper and iron. // J. Agric. Food Chem. 1992. 40. 756-759.</mixed-citation><mixed-citation xml:lang="en">Decker E.A., Crum A.D., Calvert J.T. Differences in the antioxidant mechanism of carnosine in the presence of copper and iron. // J. Agric. Food Chem. 1992. 40. 756-759.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vanin A.F., van Faassen E. // Radicals for life: The various forms of nitric oxide. (van Faassen E., Vanin A.F., eds.) / Amsterdam: Elsevier, 2007. P. 19-74.</mixed-citation><mixed-citation xml:lang="en">Vanin A.F., van Faassen E. // Radicals for life: The various forms of nitric oxide. (van Faassen E., Vanin A.F., eds.) / Amsterdam: Elsevier, 2007. P. 19-74.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yim H-S., Kang S-O., Hah Y-Ch., Chock P.B., Yim M.B. Free radicals generated during the glycation reaction of amino acids by methylglyoxal. A model study of protein-cross-linked free radicals. // J. Biol. Chem. 1995. 270. 28228-28233</mixed-citation><mixed-citation xml:lang="en">Yim H-S., Kang S-O., Hah Y-Ch., Chock P.B., Yim M.B. Free radicals generated during the glycation reaction of amino acids by methylglyoxal. A model study of protein-cross-linked free radicals. // J. Biol. Chem. 1995. 270. 28228-28233</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shumaev K.B., Kosmachevskaya O.V., Timoshin A.A., Vanin A.F., Topunov A.F. Dinitrosyl iron complexes bound with haemoglobin as markers of oxidative stress. // Methods in Enzymology. 2008. 436. 445-461.</mixed-citation><mixed-citation xml:lang="en">Shumaev K.B., Kosmachevskaya O.V., Timoshin A.A., Vanin A.F., Topunov A.F. Dinitrosyl iron complexes bound with haemoglobin as markers of oxidative stress. // Methods in Enzymology. 2008. 436. 445-461.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shumaev K.B., Dudylina A.L., Ivanova M.V., Pugachenko I.S., Ruuge E.K. Dinitrosyl iron complexes: Formation and antiradical action in heart mitochondria // Biofactors. 2018. 44. 3. 237-244.</mixed-citation><mixed-citation xml:lang="en">Shumaev K.B., Dudylina A.L., Ivanova M.V., Pugachenko I.S., Ruuge E.K. Dinitrosyl iron complexes: Formation and antiradical action in heart mitochondria // Biofactors. 2018. 44. 3. 237-244.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shumaev K.B., et al. Protective effect of dinitrosyl iron complexes with glutathione in red blood cell lysis induced by hypochlorous acid. // Oxidative Medicine and Cellular Longevity. 2019. 2019, ArticleID2798154, 12 pages. Рис. 1. Схема образования ДНКЖ, связанных с продуктами взаимодействия карнозина и метилглиоксаля (перекрестно-сшитые основания Шиффа)</mixed-citation><mixed-citation xml:lang="en">Shumaev K.B., et al. Protective effect of dinitrosyl iron complexes with glutathione in red blood cell lysis induced by hypochlorous acid. // Oxidative Medicine and Cellular Longevity. 2019. 2019, ArticleID2798154, 12 pages. Рис. 1. Схема образования ДНКЖ, связанных с продуктами взаимодействия карнозина и метилглиоксаля (перекрестно-сшитые основания Шиффа)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
