<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actbiotech</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальная биотехнология</journal-title><trans-title-group xml:lang="en"><trans-title>Topical biotechnology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-4691</issn><publisher><publisher-name>ВГУИТ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20914/2304-4691-2019-3-704-705</article-id><article-id custom-type="elpub" pub-id-type="custom">actbiotech-4423</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>УВЕЛИЧЕНИЕ ПРОДУКЦИИ L-ТРЕОНИНА ШТАММАМИ ESCHERICHIA COLI ПУТЁМ ЭКСПРЕССИИ ГЕТЕРОЛОГИЧНОЙ ЦИТРАМАЛАТСИНТАЗЫ</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Выборная</surname><given-names>Т. В.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнов</surname><given-names>Д. М.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппова</surname><given-names>С. С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синеокий</surname><given-names>С. П.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Курчатовский институт</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>18</day><month>09</month><year>2019</year></pub-date><volume>0</volume><issue>3</issue><fpage>704</fpage><lpage>705</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Выборная Т.В., Бубнов Д.М., Филиппова С.С., Синеокий С.П., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Выборная Т.В., Бубнов Д.М., Филиппова С.С., Синеокий С.П.</copyright-holder><copyright-holder xml:lang="en">Выборная Т.В., Бубнов Д.М., Филиппова С.С., Синеокий С.П.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actbio-vsuet.ru/jour/article/view/4423">https://www.actbio-vsuet.ru/jour/article/view/4423</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Биндер Т.П, Брэдшоу Д.С., Ванг М.Д. Лио Х.Д. Свишер С.Л., Хэнк П.Д. Штамм микроорганизма Escherichia coli -продуцент L-треонина, способ получения продуцирующего L-треонин штамма E.coli и способ получения L-треонина (варианты). Патент РФ RU2212448</mixed-citation><mixed-citation xml:lang="en">Биндер Т.П, Брэдшоу Д.С., Ванг М.Д. Лио Х.Д. Свишер С.Л., Хэнк П.Д. Штамм микроорганизма Escherichia coli -продуцент L-треонина, способ получения продуцирующего L-треонин штамма E.coli и способ получения L-треонина (варианты). Патент РФ RU2212448</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lee K.H., Park J.H., Kim T.Y., et al. Systems metabolic engineering of Escherichia coli for L-threonine production. Molecular systems biology. 2007, 3 (1), 1349.</mixed-citation><mixed-citation xml:lang="en">Lee K.H., Park J.H., Kim T.Y., et al. Systems metabolic engineering of Escherichia coli for L-threonine production. Molecular systems biology. 2007, 3 (1), 1349.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ma F., Wang T., Ma X., et al. Identification and characterization of protein encoded by оrf382 as L-threonine dehydrogenase. J Microbiol Biotechnol. 2014, 24. 748-755.</mixed-citation><mixed-citation xml:lang="en">Ma F., Wang T., Ma X., et al. Identification and characterization of protein encoded by оrf382 as L-threonine dehydrogenase. J Microbiol Biotechnol. 2014, 24. 748-755.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Baba T., Ara T., Hasegawa M., et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Molecular systems biology. 2006, 2 (1).</mixed-citation><mixed-citation xml:lang="en">Baba T., Ara T., Hasegawa M., et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Molecular systems biology. 2006, 2 (1).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Рыбак К.В., Сливинская Е.А, Саврасова Е.А, Казиева Е.Д., Ахвердян В.З. Способ получения L-треонина с использованием бактерии, принадлежащей к роду Escherichia, в которой инактивирован ген ltаЕ. Патент РФ RU2304166, С12N1/21, С12Р13/08, С12R1/19 2007.</mixed-citation><mixed-citation xml:lang="en">Рыбак К.В., Сливинская Е.А, Саврасова Е.А, Казиева Е.Д., Ахвердян В.З. Способ получения L-треонина с использованием бактерии, принадлежащей к роду Escherichia, в которой инактивирован ген ltаЕ. Патент РФ RU2304166, С12N1/21, С12Р13/08, С12R1/19 2007.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Schirch L.V., Gross T. Serine transhydroxymethylase identification as the threonine and allothreonine aldolases. Journal of Biological Chemistry. 1968, 243 (21), 5651-5655.</mixed-citation><mixed-citation xml:lang="en">Schirch L.V., Gross T. Serine transhydroxymethylase identification as the threonine and allothreonine aldolases. Journal of Biological Chemistry. 1968, 243 (21), 5651-5655.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pizer L.I. Glycine synthesis and metabolism in Escherichia coli. Journal of bacteriology. 1965, 89 (4), 1145- 1150.</mixed-citation><mixed-citation xml:lang="en">Pizer L.I. Glycine synthesis and metabolism in Escherichia coli. Journal of bacteriology. 1965, 89 (4), 1145- 1150.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Пак, Д.У., Ли, Б.Ч., Ким, Д.Ч., Ли, Д.Х., Чо, Д.У., Пак, У.Х. Способ получения L-треонина. Патент РФ RU2288265</mixed-citation><mixed-citation xml:lang="en">Пак, Д.У., Ли, Б.Ч., Ким, Д.Ч., Ли, Д.Х., Чо, Д.У., Пак, У.Х. Способ получения L-треонина. Патент РФ RU2288265</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Xu H., Zhang Y., Guo X., et al. Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. Journal of bacteriology. 2004, 186 (16), 5400-5409.</mixed-citation><mixed-citation xml:lang="en">Xu H., Zhang Y., Guo X., et al. Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. Journal of bacteriology. 2004, 186 (16), 5400-5409.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Т.В. Выборная, Т.В. Юзбашев, А.С. Федоров и др. Использование альтернативного пути синтеза изолейцина в штаммах Escherichia coli продуцентах треонина. Биотехнология. 2019, 35(4)</mixed-citation><mixed-citation xml:lang="en">Т.В. Выборная, Т.В. Юзбашев, А.С. Федоров и др. Использование альтернативного пути синтеза изолейцина в штаммах Escherichia coli продуцентах треонина. Биотехнология. 2019, 35(4)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
