actbiotechАктуальная биотехнологияTopical biotechnology2304-4691ВГУИТ10.20914/2304-4691-2021-1-269-272actbiotech-3811Research ArticleСтатьиРЕКОМБИНАНТНЫЕ БЕЛКИ РЕЦЕПТОРА ТИРЕОТРОПНОГО ГОРМОНА, ПОЛУЧЕНИЕ И АНАЛИЗЗубковА. В.noemail@neicon.ruКузьминаН. С.noemail@neicon.ruАндрееваМ. А.noemail@neicon.ruСидоровА. В.noemail@neicon.ruБутоваЛ. Г.noemail@neicon.ruФГБНУ НИИВС им. И.И. МечниковаRussian Federation20212209202101269272Copyright © Зубков А.В., Кузьмина Н.С., Андреева М.А., Сидоров А.В., Бутова Л.Г., 20212021Зубков А.В., Кузьмина Н.С., Андреева М.А., Сидоров А.В., Бутова Л.Г.Зубков А.В., Кузьмина Н.С., Андреева М.А., Сидоров А.В., Бутова Л.Г.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actbio-vsuet.ru/jour/article/view/3811ReferencesPastan I., Rot J.H, Macchia V. Binding of hormone to tissue: the first step in polypeptide hormone action // Proc Natl Acad Sci USA, 1966; 56(6):1802-1809.Pastan I., Rot J.H, Macchia V. Binding of hormone to tissue: the first step in polypeptide hormone action // Proc Natl Acad Sci USA, 1966; 56(6):1802-1809.Furmaniak J., Sanders J., Núñez Miguel R., B. Rees Smith. Mechanisms of Action of TSHR Autoantibodies //Horm Metab Res, 2015; 47: 735-752.Furmaniak J., Sanders J., Núñez Miguel R., B. Rees Smith. Mechanisms of Action of TSHR Autoantibodies //Horm Metab Res, 2015; 47: 735-752.Parmentier M., Libert F., Maenhaut C., Lefort A., Gerard C., Perret J., Van Sande J., Dumont J.E., Vassart G. //Molecular cloning of the thyrotropin receptor. Science. 1989; 246 (4937): 1620-1622.Parmentier M., Libert F., Maenhaut C., Lefort A., Gerard C., Perret J., Van Sande J., Dumont J.E., Vassart G. //Molecular cloning of the thyrotropin receptor. Science. 1989; 246 (4937): 1620-1622.Smith T.J. TSHR as a therapeutic target in Graves’ disease. // Expert Opin Ther Targets. 2017; 21(4): 427-432.Smith T.J. TSHR as a therapeutic target in Graves’ disease. // Expert Opin Ther Targets. 2017; 21(4): 427-432.Rapoport B., McLachlan S.M. TSH receptor cleavage into subunits and shedding of the A-subunit; a molecular and clinical perspective. //Endocrine Reviews, 2016; 37(2): 114-34.Rapoport B., McLachlan S.M. TSH receptor cleavage into subunits and shedding of the A-subunit; a molecular and clinical perspective. //Endocrine Reviews, 2016; 37(2): 114-34.Sanders J., Bolton J., Sanders P., Jeffreys J., Nakatake N., Richards T., Evans M., Kiddie A., Summerhayes S., Roberts E., Miguel R.N., Furmaniak J., Smith B.R. Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. // Thyroid. 2007; 17(2): 1195-1206.Sanders J., Bolton J., Sanders P., Jeffreys J., Nakatake N., Richards T., Evans M., Kiddie A., Summerhayes S., Roberts E., Miguel R.N., Furmaniak J., Smith B.R. Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH. // Thyroid. 2007; 17(2): 1195-1206.Gardas A., Watson P.F., Hobby P., Smith A., Weetman A.P., Sutton, B.J. and Banga J.P. Human thyroid peroxidase: mapping of autoantibodies, conformational epitopes to the enzyme surface. //Redox. Rep., 2000; 5, p. 237-241.Gardas A., Watson P.F., Hobby P., Smith A., Weetman A.P., Sutton, B.J. and Banga J.P. Human thyroid peroxidase: mapping of autoantibodies, conformational epitopes to the enzyme surface. //Redox. Rep., 2000; 5, p. 237-241.
The authors declare that there are no conflicts of interest present.